Incidental occurrence of high grade serous tubal adenocarcinoma after prophylactic adnexectomy in benign gynecological surgery

Authors: D. Kozolková 1;  B. Spodniaková 1;  M. Hajduková 2;  I. Hollý 1;  J. Záhumenský 1
Authors‘ workplace: II. gynekologicko-pôrodnícka klinika UNB a LF UK, Bratislava, prednosta doc. MUDr. J. Záhumenský, PhD. 1;  Alpha medical s. r. o, Diagnostické centrum patológie, Bratislava, generálny riaditeľ ing. P. Lednický 2
Published in: Čes. Gynek.2020, 85, č. 2 s. 111-115
Category: Case Report


Objective: Describtion of the case of incidental occurence of high grade serous tubal adenocarcinoma.

Design: Case study.

Setting: II. Department of Gynecology and Obstetrics, Medical Faculty of Comenius University and University Hospital, Bratislava.

Methods: Author observation, literature resources.

Results: Incidental occurrence of high grade serous tubal adenocarcinoma has been detected in patient after vaginal hysterectomy with bilateral adnexectomy and anterior colporhaphy.

Conclusion: Case report confirms the importance of prophylactic salpingectomy in prevention of ovarian carcinoma.


high grade serous tubal adenocarcinoma – prophylactic bilateral salpingectomy


1.    Anggraeni, TD., Al Fattah, AN., Surya, R.  Prophylactic salpingectomy and ovarian cancer: An evidence-based analysis. South Asian J Cancer, 2018, 7(1), p. 42–45.

2.    Antosh, DD., High, R., Brown, HW., et al.  Feasibility of prophylactic salpingectomy during vaginal hysterectomy. Am J Obstet Gynecol, 2017, 217, p. 605.

3.    Cibula, D., Novotný, J., Fischerová, D., et al.  Profylaktická adnexektomie. Čes Gynek, 2004, 2, p. 105–112.

4.    Committee on Gynecologic Practice. Committee opinion no. 620: Salpingectomy for ovarian cancer prevention. Obstet Gynecol, 2015, 125, p. 279–281.

5.    Crum, CP. Herfs, M., Ning, G., et al.  Through the glass darkly: Intraepithelial neoplasia, top-down differentiation, and the road to ovarian cancer. J Pathol, 2013, 231, p. 402–412.

6.    Ferlay, J., Soerjomataram, I., Dikshit, R., et al.  Cancer incidence and mortality worldwide: Sources, methods and major patterns in GLOBOCAN 2012. Int J Cancer, 2015, 136, p. E359–386.

7.    Findley, AD., Siedhoff, MT., Hobbs, KA., et al.  Short-term effects of salpingectomy during laparoscopic hysterectomy on ovarian reserve: a pilot randomized controlled trial. Fertil Steril, 2013, 100, p. 1704–8. Meserve, E.E.K., Brouwer, J., Crum, C.P. Serous tubal intraepithelial neoplasia: The concept and its application. Mod Pathol, 2017, 30, p, 710–721.

8.    Kauff, ND., Satagopan, JM., Robson, ME., et al.  Risk-reducing salpingo-oophorectomy in women with a BRCA1 or BRCA2 mutation. N Engl J Med, 2002, 346, p. 1609–1615.

9.    Kwon, JS., Tinker, A., Pansegrau, G., et al.  Prophylactic salpingectomy and delayed oophorectomy as an alternative for BRCA mutation carriers. Obstet Gynecol, 2013, 121, p. 14–24.

10.  Rebbeck, TR., Lynch, HT., Neuhausen, SL., et al.  Prophylactic oophorectomy in carriers of BRCA1 or BRCA2 mutations. N Engl J Med, 2002, 346, p. 1616–1622.

11.  Roche, K., Abu-Rustum, N., Nourmoussavi, M., et al.  Risk-reducing salpingectomy: let us be opportunistic. Cancer, 2017, 15, 123(10), p. 1714–1720.

12.  Song, T., Kim, MK., Kim, ML., et al.  Impact of opportunistic salpingectomy on anti-Mullerian hormone in patients undergoing laparoscopic hysterectomy: a multicentre randomized controlled trial. BJOG, 2016, 124(2), p. 314–320.

13.  Soong, TR., et al.  Evidence for lineage continuity between early serous proliferations (ESPs) in the fallopian tube and disseminated high-grade serous carcinomas. J Pathol, 2018, 246(3), p. 344–351.

14.  Tanner, EJ., Long, KC., Visvanathan, K., Fader, AN.  Prophylactic salpingectomy in premenopausal women at low risk for ovarian cancer: Risk-reducing or risky? Fertil Steril, 2013, 100, p. 1530–1531.

15.  Walker, JL., Powell, CB., Chen, LM., et al.  Society of Gynecologic Oncology recommendation for the prevention of ovarian cancer. Cancer, 2015, 121, p. 2108–2120.

16.  Ziętek, A., Bogusiewicz, M., Szumiło, J., Rechberger, T.  Opportunistic salpingectomy for prevention of sporadic ovarian cancer – A jump from basic science to clinical practice? Ginekol Pol, 2016, 87, p. 467–472.

17.  Zikán, M.  Profylaktické operace u žen s hereditární dispozicí ke vzniku gynekologických malignit. Čes Gynek, 2011, 76, 3, s. 216–221.

Paediatric gynaecology Gynaecology and obstetrics Reproduction medicine
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