#PAGE_PARAMS# #ADS_HEAD_SCRIPTS# #MICRODATA#

Proteomics and biomarkers for detection of cervical cancer


Authors: M. Kacerovský;  J. Tošner
Authors‘ workplace: Lékařská fakulta Hradec Králové Univerzita Karlova Praha, Porodnická a gynekologická klinika FN Hradec Králové, přednosta doc. MUDr. J. Tošner, CSc.
Published in: Ceska Gynekol 2009; 74(5): 335-338

Overview

Objective:
The purpose of this study was to focus on recent developments in the rapidly evolving field of biomarker discovery and validation techniques using proteomics platform with respect to cervical cancer.

Design:
Review.

Setting:
Department of Obstetrics and Gynecology Medical Faculty Charles University Hradec Kralove.

Methods:
The last decade has seen major changes in the technologies used to identify diagnostic markers for early stages of cervical cancer. Significant advances were achieved in three key areas: protein profilling, multidimensional liquid chromatography combined with cutting edge mass spectrometry and high-throughput validation techniques. These new technologies hold significant promise in identifying more robust, sensitive and specific markers for cervical cancer.

Conclusion:
The present review summarizes the results of clinical and experimental research on biomarkers of cervical cancer.

Key words:
proteomics, cervical cancer, biomarker.


Sources

1. Bae, SM., Lee, CH., Cho, YL., et al. Two-dimensional gel analysis of protein expression profile in squamous cervical cancer pacients. Gynecol Oncol, 2005, 99, p. 26-35.

2. Delvenne, P., Herman, L., Kholod, N., et al. Role of hormone cofactors in the human papillomavirus induced carcinogenesis of the uterine cervix. Moll Cell Endocrinol, 2007, 264, p. 1-5.

3. Choi, YP., Kang, S., Hong, S., et al. Proteomic analysis of progressive factors in uterine cervical cancer. Proteomics, 2005, 5, p. 1481-1493.

4. Kacerovský, M., Tambor, V., Lenčo, J., Tošner, J. Proteomika a karcinom ovaria. Čes Gynek, 2009, 74, p. 163-170.

5. Lin, YW., Lai, HC., Lin, CY., et al. Plasma proteomic profilig for detecting and differentiating in situ and invasive carcinomas of the uterine cervix. Int J Gynecol Cancer, 2006, 16, p. 1216-1224.

6. Martin, CM., Kehoe, L., Spillane, CO., O’Leary, JJ. Gene discovery in cervical cancer: towards diagnostic and therapuetic biomarkers. Mol Diagn Ther, 2007, 11, p. 277-290.

7. Matos, A., Moutinho, J., Pinto, D., Medeiros, R. The influence of smoking and other cofactors of the time to onset to cervical cancer in a southern European population. Eur J Cancer Prev, 2005, 14, p. 485-491.

8. Ng, G., Winder, D., Muralidhar, B., et al. Gain and overexpression of the oncostatin M receptor occur frequently in cervical squamous cell carcinoma and are associated with averse clinical outcome. J Pathol, 2007, 212, p. 325-334.

9. Nguyen, GK., Nguyen, PH., Husain, M., Husain, EM. Cervical squamous cell carcinoma and its precursor lesions: cytodiagnostic kriteria and pitfalls. Anat Pathol 1996, 1, p. 139-164.

10. Petignat, P., Roy, M. Diagnosis and management of cervical cancer. BMJ, 2007, 335, p. 765-768.

11. Rader, JS., Malone, JP., Gross, J., et al. A unified sample preparation protocol for proteomic and genomic profilig of cervical swabs to identify biomarkers of cervical cancer screening. Protemics Clin Appl, 2008, 2, p. 1-12.

12. Tjalma, WA., Van Waes, TR., Van den Eeden, LE., Bogers, JJ. Role of human papillomavirus in the carcinogenesis of squamous cell carcinoma and adenocarcinoma of the cervix. Best Pract Res Clin Obstet Gynaecol, 2005, 19, p. 469-483.

13. Wong, YF., Cheung, TH., Lo, KWK., et al. Protein profilig of cervical cancer by protein – biochips: proteomic scoring to discriminate cervical cancer from normal cervix. Cancer Letters, 2004, 221, p. 227-234.

14. Zhu, X., Lv, J., Yu, L., et al. Proteomic identification of differentially expressed proteins in squamous cervical cancer. Gynecol Oncol, 2009, 112, p. 248-256.

Labels
Paediatric gynaecology Gynaecology and obstetrics Reproduction medicine
Login
Forgotten password

Enter the email address that you registered with. We will send you instructions on how to set a new password.

Login

Don‘t have an account?  Create new account

#ADS_BOTTOM_SCRIPTS#