Medical termination of pregnancy by mifepristone and misoprostol – evaluation of succes rate, complications and satisfaction of patients


Authors: K. Frank;  R. Gerychová;  P. Janků;  M. Huser;  P. Ventruba
Authors‘ workplace: Gynekologicko-porodnická klinika LF MU a FN, Brno přednosta prof. MUDr. P. Ventruba, DrSc., MBA
Published in: Ceska Gynekol 2015; 80(6): 451-455

Overview

Objective:
The purpose of this study was to evaluate the success rate and complications of medical termination of pregnancy up to 49 days of amenorrhea and present the outcome of our phone questionaire of satisfaction of patients.

Design:
Retrospective analysis.

Setting:
Department of Obstetrics and Gynecology Masaryk University and University Hospital Brno.

Methods:
The analysis of 111 patients, who underwent medical termination of pregnancy at the Department of Obstetrics and Gynecology Masaryk University and University Hospital Brno from 1. 6. 2014 to 30. 6. 2015 using 600 mg of mifepristone (Mifegyne) and 400 µg of misoprostol (Mispregnol). In our set of patients we monitored subjective perception of medical termination of pregnancy (pain, nausea, vomiting, satisfaction with this method) and objective process (hospitalisation, surgical intervention). The view of patients was found out by the phone questionaire

Results:
Complete abortion without a surgical intervention underwent 103 patients. Nausea, pelvic pain, and intensity of bleeding were evaluated as suitable. Only 1 patient (0.9%) was hospitalised for nausea and 1 patient (0.9%) was hospitalised in case of need for an emergency curretage and transfusions. Some kind of contraception after the medical termination of pregnancy started using 98.0% of women. The satisfaction rate of this method was high – 101 patients declared themselves satisfied – 66.7% very satisfied, 24.3% rather satisfied.

Conclusion:
Medical termination of pregnancy has good efficiency, we consider it safe with minimum side-effects and is well evaluated by patients.

Keywords:
medical termination of pregnancy, mifepristone, misoprostol


Sources

1. Achilles, SL., Reeves, MF. Prevention of infection after induced abortion: release date October 2010: SFP guideline 20102. Contraception, 2011, 83, 4, p. 295–309.

2. Ashima, T., Vinita, A., Shalini, R. Early medical abortion: a new regimen up to 49 days’ gestation. Aust N Z J Obstet Gynaecol, 2005, 45, 2, p. 137–139.

3. Cleland, K., Creinin, MD., Nucatola, D., et al. Significant adverse events and outcomes after medical abortion. Obstet Gynecol, 2013, 121, 1, p. 166–171.

4. Edukační materiál o bezpečném užívání a minimalizaci rizik při použití léčivých přípravků Mifegyne® a Mispregnol® (ve znění schváleném Státním ústavem pro kontrolu léčiv ze dne 11. 11. 2013 a 16. 12. 2013).

5. Faucher, P., Baunot, N., Madelenat, P. The efficacy and acceptability of mifepristone medical abortion with home administration misoprostol provided by private providers linked with the hospital: a prospective study of 433 patients. Gynecol Obstet Fertil, 2005, 33, 4, p. 220–227.

6. Haimov-Kochman, R., Arbel, R., Brzezinski, A., et al. Risk factors for unsuccessful medical abortion with mifepristone and misoprostol. Acta Obstet Gynecol Scand, 2007, 86, 4, p. 462–466.

7. Lefebvre, P., Cotte, M., Monniez, N., Norel, G. The role of parity in medical abortion up to 49 days of amenorrhoea. Eur J Contracept Reprod Health Care, 2008, 13, 4, p. 404–411.

8. Li, YT., Hsieh, JC., Hou, GQ., et al. Simultaneous use of mifepristone and misoprostol for early pregnancy termination. Taiwan J Obstet Gynecol, 2011, 50, 1, p. 11–14.

9. Ngo, TD., Park, MH., Shakur, H., Free, C. Comparative effectiveness, safety and acceptability of medical abortion at home and in a clinic: a systematic review. Bull. World Health Organ, 2011, 89, 5, p. 360–370.

10. Nisand, I., Bettahar, K. Investigators of the aMaYa Study. Medical management of unwanted pregnancy in France: modalities and outcomes. The aMaYa study. Eur J Obstet Gynecol Reprod Biol, 2015, 184, p. 13–18.

11. Odeh, M., Tendler, R., Sosnovsky, V., et al. The effect of parity and gravidity on the outcome of medical termination of pregnancy. Isr Med Assoc J, 2010, 12, 10, p. 606–608.

12. ÚZIS. Zdravotnická ročenka České republiky 2013. s. 40.

Labels
Paediatric gynaecology Gynaecology and obstetrics Reproduction medicine
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