Primary malignant melanoma of the vagina, case report and review of the literature

Authors: J. Göbel 1;  M. Košťál 1;  G. Hensel 1;  J. Hátlová 2
Authors‘ workplace: Porodnicko-gynekologická klinika Nemocnice Pardubického kraje, přednosta doc. MUDr. M. Košťál, CSc. 1;  Patologické oddělení Nemocnice Pardubického kraje, primářka MUDr. M. Hácová 2
Published in: Ceska Gynekol 2018; 83(3): 201-199



Presentation of primary malignant melanoma of the vagina. Summary of clinical findings and management.


Case report.


Nemocnice Pardubického kraje a.s., Porodnicko-gynekologická klinika, Pardubice.


We report a case of primary malignat melanoma in a 44 year old woman, with symptoms of abnormal vaginal bleeding and painful intercourse.


Primary malignant melanoma of the vagina is rare disease. Goal of therapy is complete removal of primary tumor.


malignant melanoma, vagina


1.   Arenbergerová, M., Fialová, A., Pojezná, E. Melanom vulvy. Čes Gynek, 2013, 78, 4, s. 351–355.

2.   Buchanan, D., Schlaerth, J., Kurosaki, T. Primary vaginal melanoma: thirteen-year disease-free survival after wide local excision and review of recent literature. Am J Obstet Gynecol, 1998, 178(6), p. 11.

3.   Chen, L., Xiong, Y., Wang, H., et al. Malignant melanoma of the vagina: a case report and review of the literature. Oncol Lett, 2014, 8(4), p. 1585–1588. Epub 2014 Jul 17.

4.   Geisler, JP., Look, KY., Moore, DA., Sutton, GP. Pelvic exenteration for malignant melanomas of the vagina or urethra with over 3 mm of invasion. Gynecol Oncol, 1995, 59(3), p. 338–341.

5.   Hu, DN., Yu, GP., McCormick, SA. Population-based incidence of vulvar and vaginal melanoma in various races and ethnic groups with comparisons to other site-specific melanomas. Melanoma Res, 2010, 20(2), p. 153–158.

6.   Mario, M., Leitao, J. Management of vulvar and vaginal melanomas: current and future strategies. ASCO Educational book 2014.

7.   Miner, TJ., Delgado, R., Zeisler, J., et al. Primary vaginal melanoma: a critical analysis of therapy. Ann Surg Oncol, 2004, 11(1), p. 34–39.

8.   Oguri, H., Izumiya, C., Maeda, N., et al. A primary amelanotic melanoma of the vagina, diagnosed by immunohistochemical staining with HMB-45, which recurred as a pigmented melanoma. J Clin Pathol, 2004, 57(9), p. 986–988.

9.   Ragnarsson-Olding, B., Johansson, H., Rutqvist, LE., et al. Malignant melanoma of the vulva and vagina. Trends in incidence, age distribution, and long-term survival among 245 consecutive cases in Sweden 1960–1984. Cancer, 1993, 71(5), p. 1893–1897.

10. Rob, L., Robová, H., Pluta, M., et al. Detekce sentinelových uzlin u karcinomu vulvy – metody a technika. Čes Gynek, 2006, 71(4), s. 298–301.

11. Sugiyama, VE., Chan, JK., Kapp, DS. Management of melanomas of the female genital tract. Curr Opin Oncol, 2008, 20(5), p. 565–569.

12. Tjalma, WA., Monaghan, JM., de Barros Lopes, A., et al. Primary vaginal melanoma and long-term survivors. Eur J Gynaecol Oncol, 2001, 22(1), p. 20–22.

13. Van Nostrand, KM., Lucci, JA., Schell, M., et al. Primary vaginal melanoma: improved survival with radical pelvic surgery. Gynecol Oncol, 1994, 55(2), p. 234–237.

14. Xia, L., Han, D., Yang, W., et al. Primary malignant melanoma of the vagina: a retrospective clinicopathologic study of 44 cases. Inter J Gynecol Cancer, 2014, 24(1), p. 149–155.

Paediatric gynaecology Gynaecology and obstetrics Reproduction medicine
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