Gynecological and urological aspects of pelvic vasculitis

Authors: I. Práznovec 1;  J. Špaček jr. 2;  J. Laco 3;  V. Doničová 1;  J. Špaček 1
Authors‘ workplace: Porodnická a gynekologická klinika LF UK a FN, Hradec Králové, přednosta prof. MUDr. J. Špaček, Ph. D., IFEPAG 1;  Urologická klinika LF UK a FN, Hradec Králové, přednosta prof. MUDr. M. Broďák, Ph. D. 2;  Fingerlandův ústav patologie LF UK a FN, Hradec Králové, přednosta prof. MUDr. A. Ryška, Ph. D. 3
Published in: Ceska Gynekol 2019; 84(2): 149-153
Category: Case Report


Objective: To review contemporary knowledge of isolated vasculitis in urology and gynaecology.

Design: A review.

Setting: Department of Obstetrics and Gynaecology, University Hospital Hradec Kralove.

Methods: To present own experience and an overview of recent literature.

Conclusion: Vascular system inflammation is a very important and broadly studied medical condition. It can affect either veins or arteries. In pelvic veins it can significantly increase the risk of thromboembolic complications, while in the case of arteries; the clinical significance is still unknown. We still do not know what does the histopathological proven isolated vasculitis in this area mean. Is it just a local finding, or should we look for systemic vasculitis? Unlike most of non-symptomatic gynecological vasculitis, urological cases are often accompanied by severe symptoms depending on the anatomical location of the process. This work presents a basic overview and includes our experience with this issue. Our thesis does not include the vasculitis in pregnancy.


vasculitis – autoimmune diseases – inflammatory changes – Urology


1. Ball, GV., Fessler, BJ., Bridges, SL. Oxford textbook of vasculitis. 3rd ed. Oxford Textbooks in Rheumatology, 2014, 688 p.

2. Burger, M., Catto, JW., Dalbagni, G., et al. Epidemiology and risk factors of urothelial bladder cancer. Eur Urol. 2013, 63, p. 234–241.

3. Geisler, JP., Schraith, DF., Manahan, KJ., et al. Gemcitabine associated vasculitis leading to necrotizing enterocolitis anddeath in women undergoing primary treatment for epithelial ovarian/peritoneal cancer. Gynecol Oncol, 2004, 92, p. 705–707.

4. Hellmich, B., Kausch, I., Doehn, C., et al. Urinary bladder cancer in Wegener‘s granulomatosis: is it more than cyclophosphamide? Ann Rheum Dis, 2004, 63, p. 1183–1185.

5. Hooda, D., Parsons, J., Hooda, S., et al. Isolated bladder vasculitis: a rare presentation of Wegener‘s granulomatosis. W V Med J, 2011, 107, p. 24–26.

6. Kassir, R., Mouracade, P., Barabino, G., et al. Vasculitis of the bladder: An extremely rare case report. Int J Surg Case Rep, 2013, 4, p. 782–784.

7. Katz, D., Sengupta, S., Snow, R. Isolated vasculitis of the bladder. Urology, 2005, 65, p. 797.

8. Muñoz, A., Mañé, J., Rubio, I., et al. Gemcitabine and vascular toxicity. Lung Cancer, 2002, 37, p. 229.

9. Plaut, A. Asymptomatic focal arteritis of the appendix: eighty-eight cases. Am J Pathol, 1951, 27, p. 247.

10. Roma, AA., Amador-Ortiz, C., Liapis, H. Significance of isolated vasculitis in the gynecological tract: what clinicians do with the pathologic diagnosis of vasculitis? Ann Diagn Pathol, 2014, 18, p. 199–202.

11. Řezáč, J., Hrušková, Z., Konopásek, P., et al. Zánětlivý pseudotumor močového měchýře jako projev aktivity u pacientky s granulomatózou s polyangiitidou (Wegenerovou granulomatózou) – méně obvyklá manifestace ANCA-asociované vaskulitidy. Čes Urol, 2014, 18, s. 240–245.

12. Silva, F., Seo, P., Schroeder, DR., et al. Solid malignancies among etanercept-treated patients with granulomatosis with polyangiitis (Wegener‘s): Long-term follow-up of a multicenter longitudinal cohort. Arthrit Rheum, 2011, 63, p. 2495–2503.

13. Voorburg, A., Van Beek, F., Slee, PTJ., et al. Vasculitis due to gemcitabine. Lung Cancer, 2002, 36, p. 203–205.

14. Watts, RA., Scott, DG., Mukhtyar, C. Vasculitis in clinical practice. 2nd ed. Springer, 2015, 220 p.

Paediatric gynaecology Gynaecology and obstetrics Reproduction medicine

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