Giant breast fibroadenoma in pregnancy

Authors: Krhovský M. 1;  Pilka R. 2;  Fait V. 3;  Eim J. 1
Authors‘ workplace: Gynekologicko-porodnické oddělení, Nemocnice Vyškov p. o. 1;  Gynekologicko-porodnická klinika LF UP a FN Olomouc 2;  OMKOCH, Klinika operační onkologie LF MU a MOÚ Brno 3
Published in: Ceska Gynekol 2021; 86(2): 114-117
Category: Case Report
doi: 10.48095/cccg2021114


Objective: To present unusual case of rapidly growing breast fibroadenoma during pregnancy. Case report: Breast fibroadenomas are hormone-dependent tumors which can grow rapidly during pregnancy. We present a case of giant fibroadenoma, first detected before pregnancy, which grew rapidly under the influence of pregnancy hormones and was excised in the third trimester. Conclusion: Fibroadenomas are benign breast lesions in young women. They are hormone-dependent tumors, which can grow rapidly especially during pregnancy and/ or lactation and imitate malignancy. In each case of a newly created breast lesion, it is necessary to proceed responsibly to the clinical examination, which is a base for further decision concerning the necessity of taking a bio­psy for histological verification.


breast fibroadenoma – pregnancy – lactation – phyllodes tumor


1. Langer A, Mohallem M, Berment H et al. Breast lumps in pregnant women. Dia­gn Interv Imaging 2015; 96(10): 1077–1087. doi: 10.1016/ j.diii.2015.07.005.

2. Sládečková M, Bendová M, Kubecová M et al. Management of patient with breast carcinoma dia­gnosed during pregnancy. Ceska Gynekol 2019; 84(4): 293–297.

3. Taib NA, Rahmat K. Benign disorders of the breast in pregnancy and lactation. In: Alipour S, Omranipour R (eds). Diseases of the breast during pregnancy and lactation. Switzerland AG: Springer Nature 2020: 43–51.

4. Strnad P. Nemoci prsu v každodenní praxi. Praha: Maxdorf 2014.

5. Šašková P, Pavlišta D. Breast self-examination. Yes or no? Ceska Gynekol 2016; 81(6): 463–469.

6. Karagulle E, Turk E, Erinanc OH et al. Giant fibroadenoma growing rapidly during pregnancy. Iran Red Crescent Med J 2014; 16(8): e9531. doi: 10.5812/ ircmj.9531.

7. Halaška M, Rob L, Strnad P et al. A set of patients with breast cancer assotiated with pregnancy. Ceska Gynekol 2007; 72(3): 203–206.

8. Joshi S, Dialani V, Marotti J et al. Breast disease in the pregnant and lactating patient: radiological-pathological correlation. Insights Imaging 2013; 4(5): 527–538. doi: 10.1007/ s13244-012-0211-y.

9. Singh SK, Gupta P, Arora R et al. Giant fibroadenoma with massive infarction masquerading as malignancy: a case report. Int Cancer Conf J 2017; 6(4): 167–170. doi: 10.1007/ s13691-017-0299-5.

10. Vashi R, Hooley R, Butler R et al. Breast imaging of the pregnant and lactating patient: physiologic changes and common benign entities. AJR Am J Roentgenol 2013; 200(2): 329–336. doi: 10.2214/ AJR.12.9845.

11. Bernardi S, Londero PA, Bertozzi S et al. Breast-feeding and benign breast disease. J Obstet Gynaecol 2012; 32(1): 58–61. doi: 10.3109/ 01443615.2011.613496.

12. Špaček J, Kalousek I, Jílek P et al. Vybrané kapitoly z gynekologie. Praha: Mladá fronta 2018.

13. Komenaka IK, El-Talmer M, Pile-Spellman Eet al. Core needle bio­psy as a dia­gnostic tool to differentiate phyllodes tumor from fibro­-adenoma. Arch Surg 2003; 138(9): 987–990. doi: 10.1001/ archsurg.138.9.987.

Paediatric gynaecology Gynaecology and obstetrics Reproduction medicine

Article was published in

Czech Gynaecology

Issue 2

2021 Issue 2

Most read in this issue

This topic is also in:

Forgotten password

Don‘t have an account?  Create new account

Forgotten password

Enter the email address that you registered with. We will send you instructions on how to set a new password.


Don‘t have an account?  Create new account