Adenomyosis – its possible effect on endometrial function and receptivity

Authors: Crha K. 1;  Ješeta M. 1;  Pilka R. 2;  Ventruba P. 1;  Žáková J. 1;  Vodička J. 2;  Crha T. 1
Authors‘ workplace: Gynekologicko-porodnická klinika LF MU a FN Brno 1;  Porodnicko-gynekologická klinika LF UP a FN Olomouc 2
Published in: Ceska Gynekol 2021; 86(3): 205-209
Category: Review article
doi: 10.48095/cccg2021205


Objective: There have been many studies on adenomyosis, which can impair the quality of life of a woman. There are various kinds of opinions on the pathogenesis, dia­gnostics and treatment of adenomyosis. The goal of this article is to present the current knowledge of adenomyosis and its impact on the endometrial function and receptivity.

Methods: PubMed/Medline, Web of Sciences and Scopus were searched for the articles in English indexed until February 2021 with terms of: adenomyosis, endometrial receptivity, and infertility.

Results: Recent studies on angiogenesis and epithelial-mesenchymal transition in the endometrium bring new information on the ethiology and pathogenesis of adenomyosis. In clinical practice, the main dia­gnostic methods of adenomyosis include transvaginal ultrasound, magnetic resonance imaging or hysteroscopy, although the definitive confirmation is set by histopathological examination. The rules of #Enzian classification of endometriosis should be applied for the classification of adenomyosis. The treatment of adenomyosis should consider individual clinical presentation and reproductive plans of a patient and should be performed in centers for the treatment of endometriosis.

Conclusion: Adenomyosis affects endometrial vascularisation and epithelial-mesenchymal transition/mesenchymal-epithelial transition; thus, it can be the cause of irregular uterine bleeding or embryo implantation failure. The research and analysis of endometrial proteome could lead to the new ways of adenomyosis treatment.

Publication ethics: The Editorial Board declares that the manuscript met the ICMJE “uniform requirements” for bio medical papers.

Conflict of interests: The authors declare they have no potential conflicts of interest concerning the drugs, products or services used in the study.

Dedication: The work was supported by the Ministry of Health of the Czech Republic – RVO (FNBr: 65269705) and AZV NV-18-08-00291.


adenomyosis – infertility – endometrial receptivity – proteome – pelvic pain


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Paediatric gynaecology Gynaecology and obstetrics Reproduction medicine
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