Hormonal treatment effectivity in hyperandrogenic syndrome

Authors: J. Višňovský 1;  K. Biringer 1;  I. Švecová 1;  Z. Biringerová 2
Authors‘ workplace: Gynekologicko-pôrodnícka klinika JLF UK, Martin, Slovensko, prednosta prof. MUDr. J. Danko, CSc. 1;  Klinika anesteziológie a intenzívnej medicíny JLF UK, Martin, Slovensko, prednosta doc. MUDr. B. Sániová, CSc. 2
Published in: Ceska Gynekol 2010; 75(5): 481-485


To evaluate effectiveness of hormonal treatment of hyperandrogenic syndrome (HAS).

Prospective randomized study.

Department of Gynecology and Obstetrics, Jessenius Faculty of Medicine, Comenius University, Martin, Slovak Republic.

We assessed effect of one-year-long hormonal treatment on menstrual cycles (MC), clinical signs of HAS, and ultrasound finding (USG) in 90 patients with HAS. Patients were divided into three groups with 30 females: A – 35 μg ethinylestradiol (EE) with 2.0 mg cyproterone acetate/day; B – 30 μg EE with 2.0 mg dienogest/day; C – 30 μg EE with 3.0 mg drospirenone/day.

It was achieved a positive effect on MC regularity in every group during the first six months of treatment (p<0.001). Signs of hirsutism, virilization, and USG finding were significantly better in group A.

The most effective hormonal treatment in our study was the combination of 35 μg EE with 2.0 mg cyproterone acetate/day.

Key words:
hyperandrogenic syndrome, HAS, PCOS, menstrual bleeding, ultrasound.


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Paediatric gynaecology Gynaecology and obstetrics Reproduction medicine
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