Thrombin generation test at physiological and risk gravidity
Authors:
V. Lattová 1; M. Procházka 1; J. Úlehlová 2
Authors‘ workplace:
Porodnicko-gynekologická klinika FN, Olomouc, přednosta prof. MUDr. R. Pilka, Ph. D.
1; Hemato-onkologická klinika FN, Olomouc, přednosta prof. MUDr. K. Indrák, DrSc.
2
Published in:
Ceska Gynekol 2011; 76(5): 367-370
Overview
Generation of thrombin is pivotal step of hemostasis, according to in vitro experiments, thrombin generation occurs in 2 phases. Initially small amount of thrombin is produced after activation of factor X by complex TF / FVIIa. Thrombin multiplies coagulation by activation of platelets, F V a F VIII. Complex of TF / FVIIa activates also F VIII a, F IX, F VIII and FIXa and its binding to surface of platelets, which activates F X and products quantity of thrombin and leads formation of fibrin and finaly to triggering clotting.
Design:
Review.
Setting:
Department of Obstetrics and Gynecology, University Hospital Olomouc.
Key words:
thrombin generation test, gravidity, coagulation.
Sources
1. Castodi, E., Rosing, J. Trombin generation test, Tromb Res, 2011, 127, Suppl. 3, S21-S25.
2. Hellgren, M. Hemostasis dutinng normal pregnancy and puerperium, Semin Tromb Hemost, 2003, 29 (2), p. 125-130.
3. Hemker, HC., Giesen, P,. Aldieri, R., et al. The Calibrated Autamated Thrombogram (CAT): a universal routine tets for hyper- and hypocoagulability. Pathophysiol Heamostatis Trombosis, 2002, 3, 2, p. 249-253.
4. Procházka, M., Procházková, J., Lubušký, M., Slavík, L. Trombofilní stavy v porodnictví, I. část. Prakt Gynek, 2004, 4, p. 12-16.
Labels
Paediatric gynaecology Gynaecology and obstetrics Reproduction medicineArticle was published in
Czech Gynaecology
2011 Issue 5
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