The role of T-regulatory lymphocytes in pathogenesis of preterm delivery


Authors: H. Hrbáčková 1;  M. Koucký 1;  K. Malíčková 2;  A. Černý 1;  E. Gáborová 1;  H. Kopřivová 2;  M. Hinďoš 2
Authors‘ workplace: Gynekologicko-porodnická klinika 1. LF UK a VFN, Praha, přednosta prof. MUDr. A. Martan, DrSc. 1;  Ústav lékařské biochemie a laboratorní diagnostiky 1. LF UK a VFN, Praha, přednosta prof. MUDr. T. Zima, DrSc., MBA 2
Published in: Ceska Gynekol 2017; 82(6): 487-490

Overview

Objective:
To describe the role of T-regulatory lymphocytes in pathogenesis of preterm delivery.

Setting:
Department of Obstetrics and Gynecology, General University Hospital and 1st Medical Faculty, Charles University, Prague.

Method:
T-regulatory lymphocytes modulate the immune system, secure the tolerance to own antigens and prevent autoimmune disease. During pregnancy is maternal immunity in contact with the semi-allogeneic fetus due to the fetomaternal crosstalk. It seems that maternal immunity and T-regulatory lymphocytes have an effect on premature birth and other pregnancy pathologies. According to the latest data, their role in the immunomodulation of pregnant women seems to be very significant, although we still do not understand many mechanisms.

Keywords:
T-regulatory cells, premature birth, immunomodulation in pregancy


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Labels
Paediatric gynaecology Gynaecology and obstetrics Reproduction medicine

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