Systemic lupus erythematosus and secondary antiphospholipid syndrome in native sisters with reduced fertility

Authors: Z. Ulčová-Gallová 1,2 ;  Mukenšnabl P. 3;  Dzurillová Ž. 4;  Lošan P. 1
Authors‘ workplace: Genetika-Plzeň s. r. o., Next-Clinics Czech a. s., Plzeň 1;  Gynekologicko-porodnická klinika LF UK a FN Plzeň 2;  Šiklův ústav patologie, LF UK a FN Plzeň 3;  Medicentrum Dzurilla, Nitra, Slovensko 4
Published in: Ceska Gynekol 2022; 87(3): 198-201
Category: Case Report
doi: 10.48095/cccg2022198


Objective: Systemic lupus erythematosus (SLE) and secondary anti-phospholipid syndrome (APS II) can cause increased morbidity and mortality of the fetus. We followed the course of fertility of two sisters with these two basic diseases. Methods: In the Center for Immunology of Reproduction, we confi rmed both sisters had increased levels of some selected anti-phospholipid antibodies (against phosphatidylserine, phosphatidylethanolamine, phosphatidylinositol, DL-glycerole, anexin V, phoshatidic acid, cardiolipin, beta2-glycoprotein I), anti-nuclear, and anti-DNA antibodies. During the established immunosuppressive and hormonal therapy at the time of SLE remission, both sisters became pregnant. There was a physiological progression of pregnancy until the 19th week. Results: At the 20th week of pregnancy, the older sister miscarried again, and the younger sister developed hypertension in the 31st week of pregnancy which was terminated by caesarean section. Conclusion: In our causal evaluation, we addressed two serious autoimmune diseases (SLE, APS II) in two sisters and described their course of pregnancy. However, only one of them became a happy mother.


infertility – Systemic lupus erythematosus – secondary antiphospholipid syndrome


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Paediatric gynaecology Gynaecology and obstetrics Reproduction medicine

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