Selected pathological conditions affecting endometrial receptivity
Authors:
L. Mekiňová 1
; M Ješeta 1
; I. Crha 1,2
; K. Crha 1
; J. Vodička 3
; R. Hudeček 1
; K. Remundová 1
; E. Matušková 1
; R. Pilka 3
Authors place of work:
Gynekologicko-porodnická klinika LF MU a FN Brno
1; Ústav zdravotnických věd, LF MU Brno
2; Porodnicko-gynekologická klinika LF UP a FN Olomouc
3
Published in the journal:
Ceska Gynekol 2022; 87(6): 416-422
Category:
Přehledový článek
doi:
https://doi.org/10.48095/cccg2022416
Summary
Objective: A summary of new knowledge on embryo implantation in dependence on quality of the endometrium. Methods: Literature review from August 2022 of the relevant publications in Web of Science, Scopus and PubMed/Medline databases, focused on “endometrial receptivity”, “polycystic ovary syndrome”, “endometriosis”, “SARS-CoV-2”. Results: The receptive state of the endometrium is a result of physiological remodeling and immune system activity modulated by the microbiome. This balance can be disturbed by myomas, polyps, sactosalpings, adenomyosis, endometriosis, polycystic ovary syndrome, infections. The effect of SARS-CoV-2 infection is being discussed. For a successful implantation, timing of transfer is crucial. The ultrasound examination is used conventionally. In specific cases, hysteroscopy and endometrium biopsy are recommended. Histological and immunohistochemical evaluation is performed together with examination of microbiome or transcriptome. To support the implantation, gestagenes are used, or metformin in the patients with polycystic ovary syndrome. In cases of a repeated implantation failure, the intrauterine infusion of mononuclear cells or platelet rich plasma is used, subcutaneous application of granulocyte colony stimulating growth factor, intravenous application of atosiban or intrauterine application of human chorionic gonadotropin. Conclusion: Recent research in the field of transcriptomics, proteomics and reproductive immunology uncovers the process of implantation more deeply and opens a new stage of the assisted reproduction.
Keywords:
Endometriosis – adenomyosis – SARS-CoV-2 – proteome – implantation – receptivity of endometrium – polycystic ovaries – secretome
Zdroje
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Štítky
Dětská gynekologie Gynekologie a porodnictví Reprodukční medicínaČlánek vyšel v časopise
Česká gynekologie
2022 Číslo 6
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