Prevention of the invasion of malignant cells of gynecologic tumors during surgery


Authors: J. Kobilková 1;  J. E. Jirásek 2;  J. Jedličková 1;  O. Benešová 1;  J. Mašata 1
Authors‘ workplace: Gynekologická a porodnická klinika 1. LF UK a VFN, Praha, přednosta prof. MUDr. A. Martan, DrSc. 1;  Ústav pro péči o matku a dítě, Praha, přednosta a ředitel doc. MUDr. J. Feyereisl, DrSc. 2
Published in: Ceska Gynekol 2010; 75(6): 553-556

Overview

Objective:
In experiments performed on Vistar rats with Walker tumors, F. Luksch observed transfer of malignant cells during different manipulations into the blood circulation of the animals. During gynecologic surgery of a choriocarcinoma and of an ovarian carcinoma Luksch and Černoch prooved trace of malignant cells within the blood circulation related to the manipulation of tumors during surgery. Therefore, as prevention of the metastazing of tumor cells, they proposed to ligate ampular portions of oviducts and hypogastric vessels as the first step of the radical surgeries.

Methods:
Our observation is based on radical surgeries of 42 patients with cervical uterine carcinomas at the stage II.a (T2, N0, M0). In the first group 13 cases the ligature of oviducts and hypogastric vessels was performed at the start of the surgery. In the second group of 29 patients were operated without ligatures.

Results:
After five years in the group of 13 ligated patients 10 patients (77%) survived. In the group of 29 unligated patients only 7 (24%) were alive. The results proove substantial differences.

Conclusion:
Although the members are small, there is doubt, that the ligation of oviducts and hypogastric vessels prior radical surgeries in patients affected by malignant gynecologic tumors substantially reduces metastazing of malignant cells nad improve the five years survival of surgically treated patients with gynecologic malignant tumors.

Key words:
uterine cancer, invasion of cells, prevention.


Sources

1. Černoch, A., Luksch, F. K otázce výsevu atypických buněk při gynekologických operacích zhoubných nádorů. Čs gynek, 1962, 6-7, s. 523-528.

2. Kobilková, J., Motlík, K., Dvořák, O., Maňka, I., et al. Chirurgická a kombinovaná léčba rakoviny děložního hrdla. Závěrečná zpráva celostátního výzkumného úkolu 30.6.1980.

3. Luksch, F. Experimentelle Untersuchungen an Walkertumorzellen im kreisenden Blut on Raten. Ist International Congress of Exfoliative Cytology. Viena, Hofburg, 31.VIII-2. IX. 1961, Abstracts 60.

4. Luksch, F. Studie o atypických buňkách v krvi krys s Walkerovým nádorem. Čas Lék čes, 1961, 23, s. 712-714.

5. Maňka, I. Risk and complications in surgery treatment of uterine cervix cancer stage I. – II. Neoplasma, 1970, 17, 1, p. 69-77.

Labels
Paediatric gynaecology Gynaecology and obstetrics Reproduction medicine

Article was published in

Czech Gynaecology

Issue 6

2010 Issue 6

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