The role of maternal imunity and woman´s microbiome in the pathogenesis of preterm labor


Authors: M. Koucký 1;  K. Malíčková 2;  J. Hrdý 3;  A. Černý 1;  H. Hrbáčková 1;  P. Šimják 1;  A. Pařízek 1
Authors‘ workplace: Gynekologicko-porodnická klinika 1. LF UK a VFN, Praha, přednosta prof. MUDr. A. Martan, DrSc. 1;  Ambulance klinické a reprodukční imunologie Ústavu lékařské biochemie a laboratorní diagnostiky 1. LF UK a VFN, Praha 2;  Ústav imunologie a mikrobiologie, 1. LF UK a VFN, Praha 3
Published in: Ceska Gynekol 2017; 82(5): 407-410

Overview

Objective:
To summarize available data concerning the role of maternal imunity and woman´s microbiome in the pathogenesis of preterm labor and their use in clinical practice.

Setting:
Department of Obstetrics and Gynecology od the First Faculty of Medicine, Charles University in Prague, and General Teaching Hospital.

Design:
Review article.

Methods:
Compilation od published data from scientific literature.

Conclusion:
Preterm labor complicates approximately 10% of all pregnancies and represents a serious medical, social and economic problem. In the past, a lot of causes of preterm labor were discussed; infection, uteroplacental ischemia, decidual hemorrhage, uterine overdistension, cervical disease and maternal-fetal tolerance disorder were considered the most common. However, chronic inflammation seems to be the common pathogenic process underlying preterm labor, irrespective of the original stimulus. Currently, impaired maternal-fetal immunological tolerance represents most discussed topic. Growing scientific evidence suggests that the immune regulation of the maternal-fetal interface is the result of the coordinated interaction among maternal microbiota, trophoblast and maternal cellular components. From this view we understand preterm labor as a result of disruption of this process.

Keywords:
preterm labor, maternal-fetal immunological tolerance, maternal microbiome


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Labels
Paediatric gynaecology Gynaecology and obstetrics Reproduction medicine

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