The role of maternal imunity and woman´s microbiome in the pathogenesis of preterm labor

Authors: M. Koucký 1;  K. Malíčková 2;  J. Hrdý 3;  A. Černý 1;  H. Hrbáčková 1;  P. Šimják 1;  A. Pařízek 1
Authors‘ workplace: Gynekologicko-porodnická klinika 1. LF UK a VFN, Praha, přednosta prof. MUDr. A. Martan, DrSc. 1;  Ambulance klinické a reprodukční imunologie Ústavu lékařské biochemie a laboratorní diagnostiky 1. LF UK a VFN, Praha 2;  Ústav imunologie a mikrobiologie, 1. LF UK a VFN, Praha 3
Published in: Ceska Gynekol 2017; 82(5): 407-410


To summarize available data concerning the role of maternal imunity and woman´s microbiome in the pathogenesis of preterm labor and their use in clinical practice.

Department of Obstetrics and Gynecology od the First Faculty of Medicine, Charles University in Prague, and General Teaching Hospital.

Review article.

Compilation od published data from scientific literature.

Preterm labor complicates approximately 10% of all pregnancies and represents a serious medical, social and economic problem. In the past, a lot of causes of preterm labor were discussed; infection, uteroplacental ischemia, decidual hemorrhage, uterine overdistension, cervical disease and maternal-fetal tolerance disorder were considered the most common. However, chronic inflammation seems to be the common pathogenic process underlying preterm labor, irrespective of the original stimulus. Currently, impaired maternal-fetal immunological tolerance represents most discussed topic. Growing scientific evidence suggests that the immune regulation of the maternal-fetal interface is the result of the coordinated interaction among maternal microbiota, trophoblast and maternal cellular components. From this view we understand preterm labor as a result of disruption of this process.

preterm labor, maternal-fetal immunological tolerance, maternal microbiome


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Paediatric gynaecology Gynaecology and obstetrics Reproduction medicine

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