Treatment options for locally recurrent vulvar cancer


Authors: Ndukwe M. 1;  Práznovec I. 1;  Štěpán M. 1;  Sirák I. 2;  Fibír A. 3;  Špaček J. 1
Authors‘ workplace: Porodnická a gynekologická klinika LF UK a FN Hradec Králové 1;  Klinika onkologie a radioterapie LF UK a FN Hradec Králové 2;  Chirurgická klinika LF UK a FN Hradec Králové 3
Published in: Ceska Gynekol 2021; 86(4): 246-248
Category: Case Report
doi: 10.48095/cccg2021246

Overview

Objective: Summarizing of treatment options for locally recurrent vulvar cancer in patients after previous complex oncological treatment and presenting a case report from our department. Methods: Presenting a case report of a patient after previous complex oncological treatment for spinocellular cancer of the vulva who presented with a locally recurrent tumor. The patient was treated with a wide radical local excision of the tumor followed by a posterior thigh flap graft. Conclusion: Surgical intervention is the primary mode of treatment in locally recurrent cancers of the vulva. Wide radical local excision as a mode of treatment can be optimized by the use of grafts aiding in wound healing.

Keywords:

recurrent vulvar cancer – wide radical local excision – graft transplant – brachytherapy – Chemotherapy – Chemoradiotherapy


Sources

1. Hacker NF, Eifel PJ, van der Velden J. Cancer of the vulva. Int J Gynaecol Obstet 2012; 119 (Suppl 2): S90–S96. doi: 10.1016/S0020-7292 (12) 60021-6.

2. Maggino T, Landoni F, Sartori E et al. Pat­terns of recurrence in patients with squamous cell carcinoma of the vulva. A multicenter CTF Study. Cancer 2000; 89 (1): 116–122. doi: 10.1002/1097-0142 (20000701) 89: 1<116:: aid-cncr16>3.0.co; 2-4.

3. De Hullu JA, Hollema H, Lolkema S et al. Vulvar carcinoma. The price of less radical surgery. Cancer 2002; 95 (11): 2331–2338. doi: 10.1002/cncr.10969.

4. Piura B, Masotina A, Murdoch J et al. Recurrent squamous cell carcinoma of the vulva: a study of 73 cases. Gynecol Oncol 1993; 48 (2): 189–195. doi: 10.1006/gyno.1993.1032.

5. Rouzier R, Haddad B, Plantier F et al. Local relapse in patients treated for squamous cell vulvar carcinoma: incidence and prognostic value. Obstet Gynecol 2002; 100 (6): 1159–1167. doi: 10.1016/s0029-7844 (02) 02501-2.

6. Woolderink JM, de Bock GH, de Hullu JA et al. Patterns and frequency of recurrences of squamous cell carcinoma of the vulva. Gynecol Oncol 2006; 103 (1): 293–299. doi: 10.1016/j.ygyno.2006.03.010.

7. Heaps JM, Fu YS, Montz FJ et al. Surgical-pathologic variables predictive of local recurrence in squamous cell carcinoma of the vulva. Gynecol Oncol 1990; 38 (3): 309–314. doi: 10.1016/0090-8258 (90) 90064-r.

8. Tilmans AS, Sutton GP, Look KY et al. Recur­rent squamous carcinoma of the vulva. Am J Obstet Gynecol 1992; 167 (5): 1383–1389. doi: 10.1016/s0002-9378 (11) 91722-0.

9. Hopkins MP, Morley GW. Pelvic exenteration for the treatment of vulvar cancer. Cancer. 1992; 70 (12): 2835–2838. doi: 10.1002/1097-0142 (199212 15) 70: 12<2835:: aid-cncr2820701219>3.0.co; 2-u.

10. Miller B, Morris M, Levenback C et al. Pelvic exenteration for primary and recurrent vulvar cancer. Gynecol Oncol 1995; 58 (2): 202–205. doi: 10.1006/gyno.1995.1211.

11. Lee PK, Choi MS, Ahn ST et al. Gluteal fold V-Y advancement flap for vulvar and vaginal reconstruction: a new flap. Plast Reconstr Surg 2006; 118 (2): 401–406. doi: 10.1097/01.prs.0000227683.47836.28.

12. Weikel W, Hofmann M, Steiner E et al. Reconstructive surgery following resection of primary vulvar cancers. Gynecol Oncol 2005; 99 (1): 92–100. doi: 10.1016/j.ygyno.2005.05.031.

13. Gentileschi S, Servillo M, Garganese G et al. Surgical therapy of vulvar cancer: how to choose the correct reconstruction? J Gynecol Oncol 2016; 27 (6): e60. doi: 10.3802/jgo.2016.27.e60.

14. Tan BK, Kang GC, Tay EH et al. Subunit principle of vulvar reconstruction: algorithm and outcomes. Arch Plast Surg 2014; 41 (4): 379–386. doi: 10.5999/aps.2014.41.4.379.

15. Pirtoli L, Rottoli M. Results of radiation therapy for vulvar carcinoma. Acta Radiol Oncol 1982; 21 (1): 45–48. doi: 10.3109/02841868209133983.

16. Faul CM, Mirmow D, Huang Q et al. Adjuvant radiation for vulvar carcinoma: improved local control. Int J Radiat Oncol Biol Phys 1997; 38 (2): 381–389. doi: 10.1016/s0360-3016 (97) 82 500-x.

17. Buchler DA, Kline JC, Tunca JC et al. Treatment of recurrent carcinoma of the vulva. Gynecol Oncol 1979; 8 (2): 180–184. doi: 10.1016/0090-8258 (79) 90023-4.

18. Kellas-Ślęczka S, Białas B, Fijałkowski M et al. Interstitial high-dose-rate brachytherapy in locally advanced and recurrent vulvar cancer. J Contemp Brachytherapy 2016; 8 (1): 32–40. doi: 10.5114/jcb.2016.58081.

19. Cormio G, Loizzi V, Gissi F et al. Cisplatin and vinorelbine chemotherapy in recurrent vulvar carcinoma. Oncology 2009; 77 (5): 281–284. doi: 10.1159/000259259.

20. Singareddy R, Bajwa HK, Alluri KR et al. Carcinoma vulva patterns of recurrence and treatment outcomes: a single-institution experience. J Cancer Res Ther 2019; 15 (6):  1328–1331. doi: 10.4103/jcrt.JCRT_44_18.

Labels
Paediatric gynaecology Gynaecology and obstetrics Reproduction medicine

Article was published in

Czech Gynaecology

Issue 4

2021 Issue 4

Most read in this issue
Login
Forgotten password

Don‘t have an account?  Create new account

Forgotten password

Enter the email address that you registered with. We will send you instructions on how to set a new password.

Login

Don‘t have an account?  Create new account