Autoimmune anti-N-methyl-D-aspartate receptor encephalitis – paraneoplastic syndrome of ovarian teratoma

Authors: Benická A. 1;  Pilka R. 1;  Flodr P. 2
Authors‘ workplace: Porodnicko-gynekologická klinika LF UP a FN Olomouc 1;  Ústav klinické a molekulární patologie, LF UP a FN Olomouc 2
Published in: Ceska Gynekol 2021; 86(6): 397-399
Category: Case Report


Objective: Case presentation and subsequent dia­gnostic and therapeutic procedure of autoimmune encephalitis caused by the presence of ovarian teratoma. Case report: We describe the case of a young woman with symptoms of an acute psychotic attack unresponsive to antipsychotic treatment. Anti-N-methyl-D-aspartate receptor encephalitis was dia­gnosed within the interdisciplinary cooperation at the University Hospital in Olomouc. Conclusion: This type of rare and potentially fatal paraneoplastic limbic encephalitis occurs predominantly in young women. Due to the high variability of neuropsychiatric symptoms, the dia­gnosis of the disease is very difficult, and therefore patients are often primarily incorrectly treated for other neurological or psychiatric diseases. The most prognostically important part is early dia­gnosis and adequate therapy.


paraneoplastic syndrome – ovarian teratoma – anti-N-methyl-D-aspartate receptor encephalitis (anti-NMDAR encephalitis)


1. Mahendra IN, Saspriyana KY, Ekawati NP. Mature ovarian teratoma associated with anti-N-Methyl-D-aspartate receptor encephalitis: a case report. Med J Malaysia 2021; 76 (1): 110–113.

2. Miya K, Takahashi Y, Mori H. Anti-NMDAR autoimmune encephalitis. Brain Dev 2014; 36 (8): 645–652. doi: 10.1016/j.braindev.2013.10.005.

3. Liu CY, Zhu J, Zheng XY et al. Anti-N-Methyl-D-aspartate receptor encephalitis: a severe, potentially reversible autoimmune encephalitis. Mediators Inflamm 2017; 2017: 6361479. doi: 10.1155/2017/6361479.

4. Lee J, Kang S, Chang HJ et al. Anti-N-methyl-D-aspartate receptor encephalitis associated with ovarian teratoma in Korea. Yeungnam Univ J Med 2021. doi: 10.12701/yujm.2020.00794.

5. Li C, Meng F, Gong S. Clinical analysis of five case reports of ovarian teratoma with anti-N-methyl-D-aspartate receptor encephalitis. Ann Palliat Med 2021; 10 (4): 4950–4954. doi: 10.21037/apm-19-693.

6. Li W, Jia D, Tong L et al. Anti-N-methyl-D-aspartate receptor encephalitis induced by bilateral ovarian teratomas with distinct histopathologic types: a case report and brief literature review. Medicine (Baltimore) 2019; 98 (48): e18148. doi: 10.1097/MD.0000000000018148.

7. Janzová L, Minář L, Praksová P et al. Paraneoplastické neurologické syndromy u gynekologických malignit. Ceska Gynekol 2016; 81 (3): 186–189.

8. Dutra LA, Abrantes F, Toso FF et al. Autoimmune encephalitis: a review of dia­gnosis and treatment. Arq Neuropsiquiatr 2018; 76 (1): 41–49. doi: 10.1590/0004-282X20170176.

9. Lwin S, San Yi M, Mardiana K et al. Ovarian teratoma-associated anti-NMDAR encephalitis in a 12-year-old girl. Med J Malaysia 2020; 75 (6): 731–733.

Paediatric gynaecology Gynaecology and obstetrics Reproduction medicine
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