The role of the microbiome in pregnancy


Authors: Hornová M.;  Pařízek A.;  Koucký M.
Authors‘ workplace: Gynekologicko-porodnická klinika 1. LF UK a VFN v Praze
Published in: Ceska Gynekol 2021; 86(6): 422-427
Category: Review Article
doi: 10.48095/cccg2021422

Overview

Objective: To provide a comprehensive overview of the available information on the maternal microbio­me and its effect on pregnancy and preterm birth. Methods: Systematic review of available literature on the topic was done using the PubMed database. Conclusion: Etiology of preterm labor is multifactorial. Individual setting of humoral and cellular immune response is key; however, lately the focus has shifted to the role of the microbio­me, especially the vaginal one. The role of additional microbio­mes and the relationship between different compartments are the focus of intensive research. Mainly the differences in the maternal and neonatal microbio­me depend on the method of delivery and administration of different antibio­tics during pregnancy and labor. The uterine cavity is no longer thought to be without colonization and the formation of the fetal microbio­me begins early in pregnancy.

Keywords:

Preterm labor – microbio­me – antibio­tics – microbial invasion of amniotic cavity – vaginal seeding


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Labels
Paediatric gynaecology Gynaecology and obstetrics Reproduction medicine
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