Covid-19 as a possible risk factor of intrauterine fetal death

Authors: Válková A.;  Hubka P.
Authors‘ workplace: Gynekologicko-porodnická klinika 1. LF UK a FN Bulovka, Praha
Published in: Ceska Gynekol 2021; 86(6): 410-413
Category: Review Article
doi: 10.48095/cccg2021410


Objective: To summarize information about possible effects of covid-19 on intrauterine fetal death and present three cases of intrauterine fetal death in women with recent covid-19 infection. Methods: Review of available information about pregnancy with covid-19 and comparison with own observation of cases during spring 2021. Conclusion: Covid-19 influences risk of intrauterine fetal death, preeclampsia/eclampsia or HELLP syndrome. Coagulation changes and drop of platelets is considered as one of the causes of intrauterine fetal death due to fetal vascular malperfusion.


obstetrics – COVID-19 – intrauterine fetal death


1. Docherty AB, Harrison EM, Green CA et al. Features of 20 133 UK patients in hospital with covid-19 using the ISARIC WHO Clinical Characterisation Protocol: prospective observational cohort study. BMJ 2020; 369: m1985. doi: 10.1136/bmj.m1985.

2. Oshay RR, Chen MY, Fields BK et al. Covid-19 in pregnancy: a systematic review of chest CT findings and associated clinical features in 427 patients. Clin Imaging 2021; 75: 75–82. doi: 10.1016/j.clinimag.2021.01.004.

3. Zambrano LD, Ellington S, Strid P et al. Update: characteristics of symptomatic women of reproductive age with laboratory-confirmed SARS-CoV-2 infection by pregnancy status – United States, January 22-October 3, 2020. MMWR Morb Mortal Wkly Rep 2020; 69 (44): 1641–1647. doi: 10.15585/mmwr.mm6944e3.

4. Allotey J, Stallings E, Bonet M et al. Clinical manifestations, risk factors, and maternal and perinatal outcomes of coronavirus disease 2019 in pregnancy: living systematic review and meta-analysis. BMJ 2020; 370: m3320. doi: 10.1136/bmj.m3320.

5. Gurol-Urganci I, Jardine JE, Carroll F et al. Maternal and perinatal outcomes of pregnant women with SARS-CoV-2 infection at the time of birth in England: national cohort study. Am J Obstet Gynecol 2021; 225 (5): 522.e1–522.e11. doi: 10.1016/j.ajog.2021.05.016.

6. Knight M, Bunch K, Vousden N et al. Charac­teristics and outcomes of pregnant women admit­ted to hospital with confirmed SARS-CoV-2 infection in UK: national population based cohort study. BMJ 2020; 369: m2107. doi: 10.1136/bmj.m2107.

7. Linehan L, O‘Donoghue K, Dineen S et al. SARS-CoV-2 placentitis: an uncommon complication of maternal covid-19. Placenta 2021; 104: 261–266. doi: 10.1016/j.placenta.2021.01.012.

8. Schwartz DA, Baldewijns M, Benachi A et al. Chronic histiocytic intervillositis with tropho­blast necrosis is a risk factor associated with placental infection from coronavirus disease 2019 (covid-19) and intrauterine maternal-fetal severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) transmission in live-born and stillborn infants. Arch Pathol Lab Med 2021; 145 (5): 517–528. doi: 10.5858/arpa.2020-0771-SA.

9. RCOG. Coronavirus (covid-19) infection and pregnancy. 2021 [online]. Available from: https: //

10. ČGPS, Sekce perinatologie a fetomaternální medicíny. Těhotenství a covid-19. 2021 [online]. Dostupné z: https: //­- tenstvi-a-covid-19/.

11. Patberg ET, Adams T, Rekawek P et al. Coronavirus disease 2019 infection and placental histopathology in women delivering at term. Am J Obstet Gynecol 2021; 224 (4): 382.e1–382.e18. doi: 10.1016/j.ajog.2020.10.020.

12. Baral G, Shrestha O, Baral RS. Thrombotic pathology in placenta of covid positive pregnancy. J Nepal Health Res Counc 2021; 19 (1): 206–208. doi: 10.33314/jnhrc.v19i1.3403.

13. Richtmann R, Torloni MR, Oyamada Otani AR et al. Fetal deaths in pregnancies with SARS-CoV-2 infection in Brazil: a case series. Case Rep Womens Health 2020; 27: e00243. doi: 10.1016/j.crwh.2020.e00243.

14. Roberts DJ, Edlow AG, Romero RJ et al. SPECIAL REPORT: A standardized definition of placental infection by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), a consensus statement from the National Institutes of Health/Eunice Kennedy Shriver National Institute of Child Health and Human Development SARS-CoV-2 Placental Infection Workshop. Am J Obstet Gynecol 2021; S0002-9378 (21) 00832-2. doi: 10.1016/j.ajog.2021.07.029.

15. Zaigham M, Andersson O. Maternal and perinatal outcomes with covid‐19: a systematic review of 108 pregnancies. Acta Obstet Gynecol Scand 2020; 99 (7): 823–829. doi: 10.1111/aogs.13867.

16. Poon LC, Yang H, Lee JC et al. ISUOG Interim Guidance on 2019 novel coronavirus infection during pregnancy and puerperium: information for healthcare professionals. Ultrasound Obstet Gynecol 2020; 55 (5): 700–708. doi: 10.1002/uog.22013.

17. Calda P, Brestak M, Fischerova D et al. Coronavirus infection and pregnancy (covid-19). Statement of Czech society for ultrasound in obstetrics and gynecology. Actual Gyn 2020; 12: 17–19.

18. Mlezivova S, Machala L, Novakova D et al. Covid-19 and pregnancy. Actual Gyn 2021; 13: 26–31.

19. Juan J, Gil MM, Rong Z et al. Effect of coronavirus disease 2019 (covid‐19) on maternal, perinatal and neonatal outcome: systematic review. Ultrasound Obstet Gynecol 2020; 56 (1): 15–27. doi: 10.1002/uog.22088.

Paediatric gynaecology Gynaecology and obstetrics Reproduction medicine
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