Covid-19 as a possible risk factor of intrauterine fetal death


Authors: Válková A.;  Hubka P.
Authors‘ workplace: Gynekologicko-porodnická klinika 1. LF UK a FN Bulovka, Praha
Published in: Ceska Gynekol 2021; 86(6): 410-413
Category: Review Article
doi: 10.48095/cccg2021410

Overview

Objective: To summarize information about possible effects of covid-19 on intrauterine fetal death and present three cases of intrauterine fetal death in women with recent covid-19 infection. Methods: Review of available information about pregnancy with covid-19 and comparison with own observation of cases during spring 2021. Conclusion: Covid-19 influences risk of intrauterine fetal death, preeclampsia/eclampsia or HELLP syndrome. Coagulation changes and drop of platelets is considered as one of the causes of intrauterine fetal death due to fetal vascular malperfusion.

Keywords:

obstetrics – COVID-19 – intrauterine fetal death


Sources

1. Docherty AB, Harrison EM, Green CA et al. Features of 20 133 UK patients in hospital with covid-19 using the ISARIC WHO Clinical Characterisation Protocol: prospective observational cohort study. BMJ 2020; 369: m1985. doi: 10.1136/bmj.m1985.

2. Oshay RR, Chen MY, Fields BK et al. Covid-19 in pregnancy: a systematic review of chest CT findings and associated clinical features in 427 patients. Clin Imaging 2021; 75: 75–82. doi: 10.1016/j.clinimag.2021.01.004.

3. Zambrano LD, Ellington S, Strid P et al. Update: characteristics of symptomatic women of reproductive age with laboratory-confirmed SARS-CoV-2 infection by pregnancy status – United States, January 22-October 3, 2020. MMWR Morb Mortal Wkly Rep 2020; 69 (44): 1641–1647. doi: 10.15585/mmwr.mm6944e3.

4. Allotey J, Stallings E, Bonet M et al. Clinical manifestations, risk factors, and maternal and perinatal outcomes of coronavirus disease 2019 in pregnancy: living systematic review and meta-analysis. BMJ 2020; 370: m3320. doi: 10.1136/bmj.m3320.

5. Gurol-Urganci I, Jardine JE, Carroll F et al. Maternal and perinatal outcomes of pregnant women with SARS-CoV-2 infection at the time of birth in England: national cohort study. Am J Obstet Gynecol 2021; 225 (5): 522.e1–522.e11. doi: 10.1016/j.ajog.2021.05.016.

6. Knight M, Bunch K, Vousden N et al. Charac­teristics and outcomes of pregnant women admit­ted to hospital with confirmed SARS-CoV-2 infection in UK: national population based cohort study. BMJ 2020; 369: m2107. doi: 10.1136/bmj.m2107.

7. Linehan L, O‘Donoghue K, Dineen S et al. SARS-CoV-2 placentitis: an uncommon complication of maternal covid-19. Placenta 2021; 104: 261–266. doi: 10.1016/j.placenta.2021.01.012.

8. Schwartz DA, Baldewijns M, Benachi A et al. Chronic histiocytic intervillositis with tropho­blast necrosis is a risk factor associated with placental infection from coronavirus disease 2019 (covid-19) and intrauterine maternal-fetal severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) transmission in live-born and stillborn infants. Arch Pathol Lab Med 2021; 145 (5): 517–528. doi: 10.5858/arpa.2020-0771-SA.

9. RCOG. Coronavirus (covid-19) infection and pregnancy. 2021 [online]. Available from: https: //www.rcog.org.uk/globalassets/documents/guidelines/2021-02-19-coronavirus-covid-19-infection-in-pregnancy-v13.pdf.

10. ČGPS, Sekce perinatologie a fetomaternální medicíny. Těhotenství a covid-19. 2021 [online]. Dostupné z: https: //www.perinatologie.eu/teho­- tenstvi-a-covid-19/.

11. Patberg ET, Adams T, Rekawek P et al. Coronavirus disease 2019 infection and placental histopathology in women delivering at term. Am J Obstet Gynecol 2021; 224 (4): 382.e1–382.e18. doi: 10.1016/j.ajog.2020.10.020.

12. Baral G, Shrestha O, Baral RS. Thrombotic pathology in placenta of covid positive pregnancy. J Nepal Health Res Counc 2021; 19 (1): 206–208. doi: 10.33314/jnhrc.v19i1.3403.

13. Richtmann R, Torloni MR, Oyamada Otani AR et al. Fetal deaths in pregnancies with SARS-CoV-2 infection in Brazil: a case series. Case Rep Womens Health 2020; 27: e00243. doi: 10.1016/j.crwh.2020.e00243.

14. Roberts DJ, Edlow AG, Romero RJ et al. SPECIAL REPORT: A standardized definition of placental infection by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), a consensus statement from the National Institutes of Health/Eunice Kennedy Shriver National Institute of Child Health and Human Development SARS-CoV-2 Placental Infection Workshop. Am J Obstet Gynecol 2021; S0002-9378 (21) 00832-2. doi: 10.1016/j.ajog.2021.07.029.

15. Zaigham M, Andersson O. Maternal and perinatal outcomes with covid‐19: a systematic review of 108 pregnancies. Acta Obstet Gynecol Scand 2020; 99 (7): 823–829. doi: 10.1111/aogs.13867.

16. Poon LC, Yang H, Lee JC et al. ISUOG Interim Guidance on 2019 novel coronavirus infection during pregnancy and puerperium: information for healthcare professionals. Ultrasound Obstet Gynecol 2020; 55 (5): 700–708. doi: 10.1002/uog.22013.

17. Calda P, Brestak M, Fischerova D et al. Coronavirus infection and pregnancy (covid-19). Statement of Czech society for ultrasound in obstetrics and gynecology. Actual Gyn 2020; 12: 17–19.

18. Mlezivova S, Machala L, Novakova D et al. Covid-19 and pregnancy. Actual Gyn 2021; 13: 26–31.

19. Juan J, Gil MM, Rong Z et al. Effect of coronavirus disease 2019 (covid‐19) on maternal, perinatal and neonatal outcome: systematic review. Ultrasound Obstet Gynecol 2020; 56 (1): 15–27. doi: 10.1002/uog.22088.

Labels
Paediatric gynaecology Gynaecology and obstetrics Reproduction medicine
Login
Forgotten password

Don‘t have an account?  Create new account

Forgotten password

Enter the email address that you registered with. We will send you instructions on how to set a new password.

Login

Don‘t have an account?  Create new account