Assisted reproduction in patients with Klinefelter syndrome

Authors: K. Crha 1 ;  M Ješeta 1 ;  R. Pilka 2 ;  M. Kašík 3 ;  L. Mekiňová 1 ;  J. Vodička 2 ;  T. Crha 1
Authors‘ workplace: Gynekologicko-porodnická klinika LF MU a FN Brno 1;  Porodnicko-gynekologická klinika LF UP a FN Olomouc 2;  Urologická klinika LF MU a FN Brno 3
Published in: Ceska Gynekol 2022; 87(2): 133-136
Category: Review Article
doi: 10.48095/cccg2022133


Objective: The goal of this article is to present the current knowledge of Klinefelter syndrome and its impact on male reproductive function as well as the current treatment options. Methods: PubMed/Medline, WoS and Scopus were searched for articles indexed until November 2021. Text: Klinefelter syndrome is a chromosomal aberration with an additional X chromosome in males. This may adversely affect testicular growth and spermatogenesis, thus resulting in male infertility. Recently, new knowledge has appeared about the treatment of male infertility. Conclusion: Interdisciplinary approach enables early dia­gnosis and treatment of patients with Klinefelter syndrome. Assisted reproductive technology is essential for infertility treatment in patients with Klinefelter syndrome.


genetic testing – assisted reproduction – Aneuploidy – disorders of spermatogenesis – male sterility – Klinefelter syndrome


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Paediatric gynaecology Gynaecology and obstetrics Reproduction medicine

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