Local sperm antibodies and general levels of immunoglobulins in ovulatory cervical mucus

Authors: P. Hušáková 1;  Z. Ulčová-Gallová 2;  K. Bibková 2;  Z. Mičanová 2
Authors‘ workplace: Nemocnice Teplice, o. z., oddělení gynekologicko-porodnické, přednosta MUDr. M. Šoltés 1;  Gynekologicko-porodnická klinika LF UK a FN, Plzeň, přednosta doc. MUDr. Z. Rokyta, CSc. 2
Published in: Ceska Gynekol 2010; 75(4): 334-337


The aim of our preliminary study was to compare the levels of total local sIgA and IgG with activity of detected sperm antibodies in ovulatory cervical mucus (OCM).

Department of Gyneacology and Obstetrics, Medical School and Faculty Hospital, Charles University, Plzen.

We screened samples of OCM from 12 pacients aged 26–31 (29,6 years on average) by radial immunodifusion (RID) to determine s IgA and IgG. Indirect MAR test was used for detection of spermagglutinationg antibodies.

We found out by RID the average concentration of sIgA in OCM 567,84 mg/l (0 -1250,47) and the average concentration of IgG in OCM 23,57 mg/l (8,74–47,99). Antibody activity against sperm cells dominates in IgA with 6 pacients, in IgA with 1 patient, in IgA and IgG together with 1 infertile woman and in IgA and IgM isotypes together with 1 patient. No local sperm antibodies were determined with 3 patients.

We proved the hypothesis, that the levels of spermagglutinating antibodies do not correlate with findings of total sIgA and IgG in OCM with our patients.

Key words:
sperm agglutinating antibodies, ovulatory cervical mucus, i-MAR-test.


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Paediatric gynaecology Gynaecology and obstetrics Reproduction medicine
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