The relationship between cervicovaginal and oral HPV infection


Authors: M. Nipčová 1;  J. Sláma 2;  T. Podlešák 3;  H. Neumannová 1;  M. Zikán 1 ;  B. Sehnal 1
Authors‘ workplace: Onkogynekologické centrum, Gynekologicko-porodnická klinika, Nemocnice Na Bulovce a 1. LF UK, Praha, přednosta doc. MUDr. M. Zikán, Ph. D. 1;  Onkogynekologické centrum, Gynekologicko-porodnická klinika Všeobecné fakultní nemocnice a 1. LF UK, Praha, přednosta prof. MUDr. A. Martan, DrSc. 2;  Otorhinolaryngologické oddělení, Nemocnice Na Bulovce, Praha, primář MUDr. T. Podlešák 3
Published in: Ceska Gynekol 2018; 83(2): 133-137

Overview

Objective:
To summarize current knowledge of the relationship of genital and oral HPV infection in women.

Design:
Review article.

Setting:
Gynecologic Oncology Center, Department of Gynecology and Obstetrics, Hospital Na Bulovce and 1st Medical School of Charles University, Prague; Gynecologic Oncology Center, Department of Gynecology and Obstetrics, General Faculty Hospital and 1st Medical School of Charles University, Prague; ENT Department, Hospital Na Bulovce, Prague.

Methods and results:
The infection of human papillomavirus (HPV) is strongly associated with the development of anogenital cancers and of a subset of head and neck squamous cell cancers, yet a quite little is known about the interrelationship between oral and cervicovaginal HPV infections. A key issue in oral HPV infection is whether it can be brought about a genital HPV infection, through sexual or other contact and by autoinoculation, or whether it can be considered a fully independent event. Pertinent to this issue is the frequency of oral HPV infection in women with a cervical HPV infection. Some studies show that females with genital HPV infection are at higher risk for oral infection and HPV genotype-concordance with genital infection are more prevalent than could be expected by chance. However, more data are needed to better understand the natural history of HPV infection at each anatomic site.

Conclusion:
The relationship of oral to cervicovaginal HPV infection remains unclear. Nevertheless, published data suggest that HPV infections at these two sites are not entirely independent, although genotype-specific concordance is low.

Keywords:
human papillomavirus, genital HPV infection, cervicovaginal HPV infection, oral HPV infection


Sources

1. Bajos, N., Bozon, M., Beltzer, N., et al. Changes in sexual behaviours: from secular trends to public health policies. AIDS, 2010, 24, p. 1185–1191.

2. Brouwer, AF., Eisenberg, MC., Carey, TE., et al. Trends in HPV cervical and seroprevalence and associations between oral and genital infection and serum antibodies in NHANES 2003-2012. BMC Infect Dis, 2015, 15, p. 575. doi: 10.1186/s12879-015-1314-0.

3. Driák, D., Sehnal, B. Význam infekcí způsobených lidskými papilomaviry. Čas Lék čes, 2013, 152, s. 15–19.

4. Du, J., Nordfors, C., Ahrlund-Richter, A., et al. Prevalence of oral human papillomavirus infection among youth, Sweden. Emerg Infect Dis, 2012, 18, 9, p. 1468–1471.

5. Forman, D., de Martel, C., Lacey, CJ., et al. Global burden of human papillomavirus and related diseases. Vaccine, 2012, 30, Suppl. 5, p. F12–23. doi: 10.1016/j.vaccine.2012.07.055.

6. Gillison, ML., Chaturvedi, AK., Anderson, WF., Fakhry, C. Epidemiology of human papillomavirus–positive head and neck squamous cell carcinoma. J Clin Oncol, 2015, 33, 29, p. 3235–3242.

7. Gillison, ML., Alemany, L., Snijders, PJ., et al. Human papillomavirus and diseases of the upper airway: head and neck cancer and resipiratory papillomatosis. Vaccine, 2012, 30, Suppl. 5, p. F34–F54. doi: 10.1016/j.vaccine.2012.05.070.

8. Giuliano, AR., Nyitray, AG., Kreimer, AR., et al. EUROGIN 2014 roadmap: differences in human papillomavirus infection natural history, transmission and human papillomavirus-related cancer incidence by gender and anatomic site of infection. Int J Cancer, 2015, 136, 12, p. 2752–2760. doi: 10.1002/ijc.29082.

9. Hemminki, K., Dong, C., Frisch, M. Tonsillar and other upper aerodigestive tract cancers among cervical cancer patients and their husbands. Eur J Cancer Prev, 2000, 9, p. 433–437.

10. Chaturvedi, AK., Kleinerman, RA., Hildesheim, A., et al. Second cancers after squamous cell carcinoma and adenocarcinoma of the cervix. J Clin Oncol., 2009, 20, 6, p. 967–973.

11. Kedarisetty, S., Orosco, RK., Hecht, AS., et al. Concordant oral and vaginal human papillomavirus infection in the United States. JAMA Otolaryngol Head Neck Surg, 2016, 142, 5, p. 457–465.

12. Kreimer, AR., Bhatia, RK., Messeguer, AL., et al. Oral human papillomavirus in healthy individuals: a systematic review of the literature. Sex Transm Dis, 2010, 37, 6, p. 386–391.

13. Louvanto, K., Rautava, J., Syrjänen, K., et al. The clearance of oral high-risk human papillomavirus infection is impaired by long-term persistence of cervical human papillomavirus infection. Clin Microbiol Infect, 2014, 20, 11, p. 1167–1172.

14. Marques, AE., Barra, GB., de Resende Oyama, CN., et al. Low rate of oropharyngeal human papillomavirus infection of women with cervical lesions and their partners: new data from Brazilian population. J Oral Pathol Med, 2015, 44, 6, p. 453–458.

15. Meyer, MF., Huebbers, CU., Siefer, OG., et al. Prevalence and risk factors for oral human papillomavirus infection in 129 women screened for cervical HPV infection. Oral Oncol, 2014, 50, 1, p. 27–31.

16. Michl, P., Procházka, M., Štosová, T., et al. HPV v etiologii orofaryngeálního karcinomu a jeho vztah k sexuální aktivitě. Čes Gynek, 2015, 80, 1, s. 30–36.

17. Mladěnka, A., Kubečková, A., Sláma, J. Aktuální poznatky o HPV infekci. Čes Gynek, 2016, 81, 5, s. 369–375.

18. Oliveira, LH., Santos, LS., Silva, CO., et al. Papillomavirus infections in the oral and genital mucosa of asymptomatic women. Braz J Infect Dis, 2017, 21, p. 88–91.

19. Sehnal, B., Driák, D., Neumannová, H., et al. Prevalence anální HPV infekce u žen a její vztah k cervikální HPV infekci. Čes Gynek, 2012, 77, 3, s. 210–214.

20. Sehnal, B., Vojáčková, N., Driák, D., et al. Předpokládaná účinnost HPV vakcinace v profylaxi nongenitálních karcinomů. Klin Onkol, 2014, 27, 4, s. 239–246.

21. Sehnal, B., Dusek, L., Cibula, D., et al. The relationship between the cervical and anal HPV infection in women with cervical intraepithelial neoplasia. J Clin Virol, 2014, 59, 1, p. 18–23.

22. Shigeishi, H., Sugiyama, M. Risk factors for oral human papillomavirus infection in healthy individuals: a systematic review and meta-analysis. J Clin Med Res, 2016, 8, 10, p. 721–729.

23. Shvetsov, YB., Hernandez, BY., McDuffie, K., et al. Duration and clearance of anal human papillomavirus (HPV) infection among women: the Hawaii HPV cohort study. Clin Infect Dis, 2009, 48, 5, p. 536–546.

24. Steinau, M., Hariri, S., Gillison, ML., et al. Prevalence of cervical and oral human papillomavirus infections among US women. J Infect Dis, 2014, 209, 11, p. 1739–1743.

25. Termine, N., Giovannelli, L., Matranga, D., et al. Oral human papillomavirus infection in women with cervical HPV infection: new data from an Italian cohort and a meta-analysis of the literature. Oral Oncol, 2011, 37, 4, p. 244–250.

26. Visalli, G., Curro, M., Facciolà, A., et al. Prevalence of human papillomavirus in saliva of women with HPV genital lesions. Infect Agent Cancer, 2016, 26, 1, p. 48. doi: 10.1186/s13027-016-0096-3. eCollection 2016.

Labels
Paediatric gynaecology Gynaecology and obstetrics Reproduction medicine
Login
Forgotten password

Enter the email address that you registered with. We will send you instructions on how to set a new password.

Login

Don‘t have an account?  Create new account