Metaanalýza souvislosti varianty COMT Val158Met s rizikem preeklampsie

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Autoři: S. Jangde ¹ ; B. Meher ¹ ; N. Sahu ¹ ; H. K. Verma ² ; L. V. K. S. Bhaskar ¹
Působiště autorů: Department of Zoology, Guru Ghasidas Vishwavidyalaya, Bilaspur, India ¹; Department of Bioscience and Biomedical Engineering, Indian Institute of Technology, Bhilai, India ²
Vyšlo v časopise: Ceska Gynekol 2026; 91(4): 314-321
Kategorie: Původní práce
doi: https://doi.org/10.48095/cccg2026314

Souhrn

Katecholamin-O-metyltransferáza (COMT) katalyzuje O-metylaci sloučenin s katecholovou strukturou, jako jsou katecholaminy a katecholestrogeny. Genetická varianta v lidském genu COMT (rs4680 nebo Val158Met) významně snižuje metabolizmus katecholaminů 3krát až 4krát, ovlivňuje hladiny neurotransmiterů a tím moduluje náchylnost k preeklampsii (PE). Tato metaanalýza byla provedena za účelem vyhodnocení souvislosti mezi variantou COMT Val158Met a rizikem PE. Byly systematicky prohledány případově-kontrolní studie publikované do 20. listopadu 2025 v databázích PubMed, Google Scholar a Web of Science. Pro posouzení souvislosti mezi variantou COMT Val158Met a PE byly vypočítány poměry šancí (OR) a 95% intervaly spolehlivosti v rámci tří genetických modelů. Výsledky neprokázaly žádnou významnou souvislost mezi variantou COMT Val158Met a rizikem PE v žádném ze tří genetických modelů, vč. alelického (Met vs. Val: celkový OR 1,19; 95% CI 1,00–1,43; p = 0,052), recesivního (Met/Met + Met/Val vs. Val/Val: celkový OR 1,16; 95% CI 0,95–1,40; p = 0,137) a dominantní (Met/Met vs. Met/Val + Val/Val, OR 1,39; 95% CI 0,97–2,00; p = 0,075). Analýzy podskupin založené na etnickém původu rovněž neprokázaly žádnou souvislost mezi variantou Val158Met a rizikem PE u kavkazské a asijské populace. Analýzy citlivosti provedené metodou „leave-one-out“ ukázaly, že výsledky jsou robustní. Asymetrie pozorovaná v Beggově trychtýřovém grafu naznačovala významnou publikační zaujatost v dominantním modelu (p = 0,012). Souhrnně lze říci, že výsledky ukázaly, že varianta COMT Val158Met není spojena s rizikem PE. Jelikož tato metaanalýza odporuje biologické pravděpodobnosti, že alely COMT ovlivňují katecholaminové neurotransmitery a PE, je třeba výsledky interpretovat opatrně a provést další výzkum.

Klíčová slova:

metaanalýza – preeklampsie – katecholamin-O-metyltransferáza – varianta Val158Met

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Zdroje

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